1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea is a chemical compound with the following structural formula:
```
Cl
\\
C - NH - C(=S) - NH - CH2 - C
/ \\
Cl Cl
```
It is a **thiourea derivative** containing two chlorophenyl groups. This specific compound is not widely studied or known for any particular significant research applications.
However, thioureas in general are a class of compounds with diverse applications in various fields:
**1. Pharmaceuticals:**
* **Anti-cancer agents:** Some thioureas show promising anticancer activity by inhibiting the growth of cancer cells.
* **Anti-inflammatory agents:** Thioureas can possess anti-inflammatory properties, potentially useful in treating various inflammatory conditions.
* **Antibiotics:** Some thiourea derivatives exhibit antibiotic activity, inhibiting the growth of bacteria.
* **Antiviral agents:** Research indicates that certain thioureas can inhibit the activity of viruses, potentially leading to antiviral treatments.
**2. Agriculture:**
* **Herbicides:** Thioureas are used in herbicides to control weed growth in agricultural fields.
* **Fungicides:** Some thioureas possess fungicidal activity, protecting crops from fungal diseases.
**3. Materials Science:**
* **Polymers:** Thioureas are employed in the synthesis of polymers, contributing to the development of novel materials with specific properties.
* **Dyeing:** Thioureas are used as intermediates in the synthesis of dyes, providing vibrant colors for textiles and other applications.
**4. Analytical Chemistry:**
* **Reagents:** Thioureas serve as reagents in various analytical methods, enabling the detection and quantification of specific compounds.
**5. Other Applications:**
* **Corrosion inhibitors:** Thioureas are employed as corrosion inhibitors in various industrial applications, preventing metal degradation.
* **Stabilizers:** Thioureas can act as stabilizers in various materials, improving their durability and performance.
**Therefore, while the specific compound you mentioned, 1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea, might not be widely researched, its structure suggests potential for similar applications as other thiourea derivatives. Its significance could arise if its specific properties are found to be advantageous in a particular research area.**
To determine the specific importance of this compound, you would need to look for published research on its synthesis, characterization, and biological or chemical activity.
ID Source | ID |
---|---|
PubMed CID | 972574 |
CHEMBL ID | 1448773 |
CHEBI ID | 105036 |
Synonym |
---|
AKOS002332390 |
smr000294740 |
n-(2-chlorobenzyl)-n'-(2-chlorophenyl)thiourea |
MLS000665044 , |
1-(2-chlorobenzyl)-3-(2-chlorophenyl)thiourea |
STK164708 |
CHEBI:105036 |
1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea |
HMS2683D24 |
bdbm44093 |
cid_972574 |
CHEMBL1448773 |
Q27182714 |
Class | Description |
---|---|
thioureas | Compounds of general formula RR'NC(=S)NR''R'''. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.1838 | 5.6234 | 17.2929 | 31.6228 | AID485281 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 50.1187 | 3.9811 | 27.7649 | 39.8107 | AID504842 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 15.8489 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
huntingtin isoform 2 | Homo sapiens (human) | Potency | 7.0795 | 0.0006 | 18.4198 | 1,122.0200 | AID1688 |
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 89.1251 | 0.4256 | 12.0591 | 28.1838 | AID504891 |
DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 1.6903 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 0.0158 | 12.3113 | 615.5000 | AID1461 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
electroneutral potassium-chloride cotransporter KCC2 | Homo sapiens (human) | EC50 (µMol) | 5.7400 | 0.4810 | 1.5303 | 2.3100 | AID1736 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |