Page last updated: 2024-12-09

1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea is a chemical compound with the following structural formula:

```
Cl
\\
C - NH - C(=S) - NH - CH2 - C
/ \\
Cl Cl
```

It is a **thiourea derivative** containing two chlorophenyl groups. This specific compound is not widely studied or known for any particular significant research applications.

However, thioureas in general are a class of compounds with diverse applications in various fields:

**1. Pharmaceuticals:**

* **Anti-cancer agents:** Some thioureas show promising anticancer activity by inhibiting the growth of cancer cells.
* **Anti-inflammatory agents:** Thioureas can possess anti-inflammatory properties, potentially useful in treating various inflammatory conditions.
* **Antibiotics:** Some thiourea derivatives exhibit antibiotic activity, inhibiting the growth of bacteria.
* **Antiviral agents:** Research indicates that certain thioureas can inhibit the activity of viruses, potentially leading to antiviral treatments.

**2. Agriculture:**

* **Herbicides:** Thioureas are used in herbicides to control weed growth in agricultural fields.
* **Fungicides:** Some thioureas possess fungicidal activity, protecting crops from fungal diseases.

**3. Materials Science:**

* **Polymers:** Thioureas are employed in the synthesis of polymers, contributing to the development of novel materials with specific properties.
* **Dyeing:** Thioureas are used as intermediates in the synthesis of dyes, providing vibrant colors for textiles and other applications.

**4. Analytical Chemistry:**

* **Reagents:** Thioureas serve as reagents in various analytical methods, enabling the detection and quantification of specific compounds.

**5. Other Applications:**

* **Corrosion inhibitors:** Thioureas are employed as corrosion inhibitors in various industrial applications, preventing metal degradation.
* **Stabilizers:** Thioureas can act as stabilizers in various materials, improving their durability and performance.

**Therefore, while the specific compound you mentioned, 1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea, might not be widely researched, its structure suggests potential for similar applications as other thiourea derivatives. Its significance could arise if its specific properties are found to be advantageous in a particular research area.**

To determine the specific importance of this compound, you would need to look for published research on its synthesis, characterization, and biological or chemical activity.

Cross-References

ID SourceID
PubMed CID972574
CHEMBL ID1448773
CHEBI ID105036

Synonyms (13)

Synonym
AKOS002332390
smr000294740
n-(2-chlorobenzyl)-n'-(2-chlorophenyl)thiourea
MLS000665044 ,
1-(2-chlorobenzyl)-3-(2-chlorophenyl)thiourea
STK164708
CHEBI:105036
1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea
HMS2683D24
bdbm44093
cid_972574
CHEMBL1448773
Q27182714
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
thioureasCompounds of general formula RR'NC(=S)NR''R'''.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Ferritin light chainEquus caballus (horse)Potency28.18385.623417.292931.6228AID485281
glp-1 receptor, partialHomo sapiens (human)Potency28.18380.01846.806014.1254AID624417
chaperonin-containing TCP-1 beta subunit homologHomo sapiens (human)Potency50.11873.981127.764939.8107AID504842
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency15.84890.011212.4002100.0000AID1030
chromobox protein homolog 1Homo sapiens (human)Potency100.00000.006026.168889.1251AID540317
huntingtin isoform 2Homo sapiens (human)Potency7.07950.000618.41981,122.0200AID1688
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency89.12510.425612.059128.1838AID504891
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency1.69030.00798.23321,122.0200AID2546; AID2551
neuropeptide S receptor isoform AHomo sapiens (human)Potency12.58930.015812.3113615.5000AID1461
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
electroneutral potassium-chloride cotransporter KCC2Homo sapiens (human)EC50 (µMol)5.74000.48101.53032.3100AID1736
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]